The Cutting Edge of San Francisco Biotech Real Estate
Known as the “birthplace of biotechnology,” San Francisco is home to hundreds of biotech companies occupying multi-millions of square feet of real estate, with more development on the horizon. With South San Francisco being one of the largest biotech clusters in the world, it attracts a surge of well-educated candidates for the labor market and an abundance of large biotech and pharmaceutical companies alongside venture firms in close proximity. HM Science, a specialized life science division of Hughes Marino, provides life science companies throughout the Bay Area with best-in-class, bespoke corporate real estate services specializing in the unique needs and critical specifications of the industry. Backed by over three decades of expertise in the field, our HM Science team has represented life science companies large and small with millions of square feet of state-of-the-art laboratory and biotech space.
An Outsourced Real Estate Partner With A Life Science Focus
- BIOTECHNOLOGY
- GMP MANUFACTURING
- CLIA TESTING LABORATORIES
- PATHOLOGY
- MEDICAL DEVICE & DIAGNOSTICS
- DIAGNOSTICS & TESTING LABORATORIES
- INDUSTRIAL BIOTECH
- PHARMACEUTICAL
- COMMERCIAL SCALE-UPS
- HEALTH TECHNOLOGY

Putting Decades of Life Science Real Estate Experience to Work
Our immersion in the San Francisco life science market over the years has helped us cultivate a community of experts within this sector. Along with our extensive experience in sectors ranging from biotechnology, GMP manufacturing, CLIA testing laboratories, medical device & diagnostics and more, allows us to provide the right solutions to help your company succeed. We specialize in serving life science companies from needs assessment, site selection and lab planning, leasing, renewing, expanding, subleasing, buying a building or building a lab space from the ground-up. Instead of defining our clients’ issues to fit our capabilities, we listen to their needs, assess the specific lab and testing requirements required, and tailor solutions to help them meet their long-term goals of finding the right space for their business.
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Details We Take Into Consideration
- Back-up generators and power requirements
- Lab HVAC and handling requirements
- Tissue culture room designs and MEP/HVAC requirements
- Clean rooms including all ISO levels and CLIA
- Benching styles based on scientific procedures
- Hazardous materials storage
- House vs. tenant provided services
- Number of control zones
- Animal care and vivariums
- Building engineering/support on a 24/7 basis
- Floor load capacity
- Vibration sensitive equipment
- Freight elevator requirements
- Natural light in lab areas
- Water needs
- Gas requirements and hookups
- Chemical limits
- Flammable limits
- Lab IT and data needs
- Equipment planning
- Lab MEP planning
- Physical and cultural connection between lab and office
Our Life Science Locations
With offices in every major life science hub in the U.S., our team has experience assisting biotech clients in every market in the country. We offer local expertise to our clients with facilities from east to west and everywhere in between—Boston to San Diego, Raleigh-Durham to Seattle, San Francisco to Boulder, and around the world.

Testimonials
Whether you’re looking for your first lab space or expanding your national lab footprint, we specialize in serving life science companies with every facility need. From leasing, renewing, expanding, buying a building or building a lab space from the ground-up, our focus and specialization in biotech makes us trusted experts in everything life science companies need for success.
Frequently Asked Questions
Lab, testing, production, fulfillment and R&D facilities require specialized infrastructure, engineering and regulatory considerations that go far beyond traditional office or industrial environments.
Most organizations in San Francisco benefit from starting 12 to 18 months ahead of a potential move or renewal so they can evaluate all scientific, operational and financial variables.
Our team partners closely with architects, engineers, planners and project managers to ensure scientific workflows, technical requirements and long-term needs are fully supported.
We work with a broad range of organizations in San Francisco including biotechnology, pharmaceutical, medical device, diagnostics, GMP manufacturing and clinical laboratories, helping companies at all stages—from startups to global enterprises.
Yes. Our team provides full tenant and buyer representation, whether you’re expanding, relocating or purchasing space for labs, offices or full campuses.
Absolutely. We offer in-house architects, lab planners and construction project managers to ensure your space meets scientific, operational and regulatory requirements.
We consider factors like proximity to talent, supply chain logistics, research hubs and long-term growth plans to secure locations that align with your business strategy.
Yes. Our team has extensive experience negotiating agreements in San Francisco of all sizes and complexities, helping ensure favorable terms and predictable costs for our clients.
Yes. While we are U.S.-based, we provide strategy, insight and representation for life science companies across the country and around the globe.
Meet Our Team of World-Class
Life Science Real Estate Experts
Widely recognized as the corporate real estate partner of choice for life science companies across the nation, we are proud to bring our three decades of specialization and best of class representation to our clients no matter where they operate and what their needs are.
The Following Life Science Organizations Are Proudly Supported by Hughes Marino:



























